2001 ASPET OTTO KRAYER AWARD LECTURE:

Erik De Clercq

Molecular Targets for Antiviral Agents
J Pharmacol Exp Ther 2001 297: 1-10. [Abstract] [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

David A. Taylor and William W. Fleming

Unifying Perspectives of the Mechanisms Underlying the Development of Tolerance and Physical Dependence to Opioids
J Pharmacol Exp Ther 2001 297: 11-18. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

E. Stacy Ward, Gary M. Pollack, and Kim L. R. Brouwer

Probenecid-Associated Alterations in Valproate Glucuronide Hepatobiliary Disposition: Mechanistic Assessment Using Mathematical Modeling
J Pharmacol Exp Ther 2001 297: 141-147. [Abstract] [Full Text] [PDF]  

Heinrich Iber, Tong Li-Masters, Qi Chen, Sheng Yu, and Edward T. Morgan

Regulation of Hepatic Cytochrome P450 2C11 via cAMP: Implications for Down-Regulation in Diabetes, Fasting, and Inflammation
J Pharmacol Exp Ther 2001 297: 174-180. [Abstract] [Full Text] [PDF]  

Veronica Werlinder, Maria Backlund, Andrei Zhukov, and Magnus Ingelman-Sundberg

Transcriptional and Post-Translational Regulation of CYP1A1 by Primaquine
J Pharmacol Exp Ther 2001 297: 206-214. [Abstract] [Full Text] [PDF]  

Karthik Venkatakrishnan, Lisa L. von Moltke, and David J. Greenblatt

Application of the Relative Activity Factor Approach in Scaling from Heterologously Expressed Cytochromes P450 to Human Liver Microsomes: Studies on Amitriptyline as a Model Substrate
J Pharmacol Exp Ther 2001 297: 326-337. [Abstract] [Full Text] [PDF]  

Yutaka Oda and Evan D. Kharasch

Metabolism of levo--Acetylmethadol (LAAM) by Human Liver Cytochrome P450: Involvement of CYP3A4 Characterized by Atypical Kinetics with Two Binding Sites
J Pharmacol Exp Ther 2001 297: 410-422. [Abstract] [Full Text] [PDF]  

Eugene Tan, Thanh Lu, and K. Sandy Pang

Futile Cycling of Estrone Sulfate and Estrone in the Recirculating Perfused Rat Liver Preparation
J Pharmacol Exp Ther 2001 297: 423-436. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

C. M. McKune and S. W. Watts

Characterization of the Serotonin Receptor Mediating Contraction in the Mouse Thoracic Aorta and Signal Pathway Coupling
J Pharmacol Exp Ther 2001 297: 88-95. [Abstract] [Full Text] [PDF]  

Jocelyn Bérubé, David Caouette, and Pascal Daleau

Hydrogen Peroxide Modifies the Kinetics of HERG Channel Expressed in a Mammalian Cell Line
J Pharmacol Exp Ther 2001 297: 96-102. [Abstract] [Full Text] [PDF]  

Saadia Eddahibi, Serge Adnot, Eric Frisdal, Micheline Levame, Michel Hamon, and Bernadette Raffestin

Dexfenfluramine-Associated Changes in 5-Hydroxytryptamine Transporter Expression and Development of Hypoxic Pulmonary Hypertension in Rats
J Pharmacol Exp Ther 2001 297: 148-154. [Abstract] [Full Text] [PDF]  

Moses S. S. Chow, Chengde Fan, Hieu Tran, Hong Zhao, and Li Zhou

Effects of Diaspirin Cross-Linked Hemoglobin (DCLHb) during and Post-CPR in Swine
J Pharmacol Exp Ther 2001 297: 224-229. [Abstract] [Full Text] [PDF]  

Guei-Jane Wang, Andrew Yau-Chik Shum, Yun-Lian Lin, Jyh-Fei Liao, Xi-Chen Wu, Jun Ren, and Chieh-Fu Chen

Calcium Channel Blockade in Vascular Smooth Muscle Cells: Major Hypotensive Mechanism of S-Petasin, a Hypotensive Sesquiterpene from Petasites formosanus
J Pharmacol Exp Ther 2001 297: 240-246. [Abstract] [Full Text] [PDF]  

Delvin R. Knight, Andrew H. Smith, David M. Flynn, Joseph T. MacAndrew, Suzanne S. Ellery, Jimmy X. Kong, Ravi B. Marala, Ronald T. Wester, Angel Guzman-Perez, Roger J. Hill, William P. Magee, and W. Ross Tracey

A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo
J Pharmacol Exp Ther 2001 297: 254-259. [Abstract] [Full Text] [PDF]  

Timothy E. Morey, Christoph N. Seubert, M. J. Pekka Raatikainen, Anatoly E. Martynyuk, Pascal Druzgala, Peter Milner, Mario D. Gonzalez, and Donn M. Dennis

Structure-Activity Relationships and Electrophysiological Effects of Short-Acting Amiodarone Homologs in Guinea Pig Isolated Heart
J Pharmacol Exp Ther 2001 297: 260-266. [Abstract] [Full Text] [PDF]  

Gary J. Hom, Michael J. Forrest, Thomas J. Bach, Edward Brady, Mari Rios Candelore, Margaret A. Cascieri, Donna J. Fletcher, Michael H. Fisher, Susan A. Iliff, Robert Mathvink, Joseph Metzger, Victor Pecore, Richard Saperstein, Thomas Shih, Ann E. Weber, Matthew Wyvratt, Peter Zafian, and D. Euan MacIntyre

₃-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys
J Pharmacol Exp Ther 2001 297: 299-307. [Abstract] [Full Text] [PDF]  

Giuseppe Rossoni, Barbara Manfredi, Vito De Gennaro Colonna, Micaela Bernareggi, and Ferruccio Berti

The Nitroderivative of Aspirin, NCX 4016, Reduces Infarct Size Caused by Myocardial Ischemia-Reperfusion in the Anesthetized Rat
J Pharmacol Exp Ther 2001 297: 380-387. [Abstract] [Full Text] [PDF]  

José A. Sánchez-Chapula, Eduardo Salinas-Stefanon, Julian Torres-Jácome, Dora E. Benavides-Haro, and Ricardo A. Navarro-Polanco

Blockade of Currents by the Antimalarial Drug Chloroquine in Feline Ventricular Myocytes
J Pharmacol Exp Ther 2001 297: 437-445. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Dimcho R. Bachvarov, Steeve Houle, Magdalena Bachvarova, Johanne Bouthillier, Albert Adam, and François Marceau

Bradykinin B₂ Receptor Endocytosis, Recycling, and Down-Regulation Assessed Using Green Fluorescent Protein Conjugates
J Pharmacol Exp Ther 2001 297: 19-26. [Abstract] [Full Text] [PDF]  

Chifumi Nagano, Atsushi Azuma, Hironobu Ishiyama, Kazuo Sekiguchi, Kenichi Imagawa, and Mikio Kikuchi

Rebamipide Suppresses Formyl-methionyl-leucyl-phenylalanine (fMLP)-Induced Superoxide Production by Inhibiting fMLP-Receptor Binding in Human Neutrophils
J Pharmacol Exp Ther 2001 297: 388-394. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Michael R. Boyd, Carlo Farina, Pietro Belfiore, Stefania Gagliardi, Jin Woo Kim, Yoichi Hayakawa, John A. Beutler, Tawnya C. McKee, Barry J. Bowman, and Emma Jean Bowman

Discovery of a Novel Antitumor Benzolactone Enamide Class That Selectively Inhibits Mammalian Vacuolar-Type (H⁺)-ATPases
J Pharmacol Exp Ther 2001 297: 114-120. [Abstract] [Full Text] [PDF]  

Jiu-Haw Yin, Ding-I Yang, Henry Chou, Ellen M. Thompson, Jan Xu, and Chung Y. Hsu

Inducible Nitric Oxide Synthase Neutralizes Carbamoylating Potential of 1,3-Bis(2-chloroethyl)-1-nitrosourea in C6 Glioma Cells
J Pharmacol Exp Ther 2001 297: 308-315. [Abstract] [Full Text] [PDF]  

Masahiko Kurokawa, Toyoharu Hozumi, Minako Tsurita, Shigetoshi Kadota, Tsuneo Namba, and Kimiyasu Shiraki

Biological Characterization of Eugeniin as an Anti-Herpes Simplex Virus Type 1 Compound in Vitro and in Vivo
J Pharmacol Exp Ther 2001 297: 372-379. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Shiyao Xu, Bao Ting Zhu, May Xiaoxin Cai, and Allan H. Conney

Stimulatory Effect of Clofibrate on the Action of Estradiol in the Mammary Gland but Not in the Uterus of Rats
J Pharmacol Exp Ther 2001 297: 50-56. [Abstract] [Full Text] [PDF]  

Robert Elsby, James L. Maggs, John Ashby, and B. Kevin Park

Comparison of the Modulatory Effects of Human and Rat Liver Microsomal Metabolism on the Estrogenicity of Bisphenol A: Implications for Extrapolation to Humans
J Pharmacol Exp Ther 2001 297: 103-113. [Abstract] [Full Text] [PDF]  

Jorge A. Carvajal, Kripamoy Aguan, Loren P. Thompson, Irina A. Buhimschi, and Carl P. Weiner

Natriuretic Peptide-Induced Relaxation of Myometrium from the Pregnant Guinea Pig Is Not Mediated by Guanylate Cyclase Activation
J Pharmacol Exp Ther 2001 297: 181-188. [Abstract] [Full Text] [PDF]  

Q. David Walker, Reynold Francis, Jose Cabassa, and Cynthia M. Kuhn

Effect of Ovarian Hormones and Estrous Cycle on Stimulation of the Hypothalamo-Pituitary-Adrenal Axis by Cocaine
J Pharmacol Exp Ther 2001 297: 291-298. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Junru Wang, Huaien Zheng, and Martin Hauer-Jensen

Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor (TGF-) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine
J Pharmacol Exp Ther 2001 297: 35-42. [Abstract] [Full Text] [PDF]  

Eduardo R. Lazarowski, Lori G. Rochelle, Wanda K. O'Neal, Carla M. P. Ribeiro, Barbara R. Grubb, Vivian Zhang, T. Kendall Harden, and Richard C. Boucher

Cloning and Functional Characterization of Two Murine Uridine Nucleotide Receptors Reveal a Potential Target for Correcting Ion Transport Deficiency in Cystic Fibrosis Gallbladder
J Pharmacol Exp Ther 2001 297: 43-49. [Abstract] [Full Text] [PDF]  

Sutthasinee Poonyachoti, Philip S. Portoghese, and David R. Brown

Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That - and -Opioid Receptors Are Coexpressed in Myenteric Neurons
J Pharmacol Exp Ther 2001 297: 69-77. [Abstract] [Full Text] [PDF]  

Katja Eichert, Jürg Hamacher, Michael Andreas Wunder, and Albrecht Wendel

Intravasal Peroxynitrite Generation Causes Dysfunction in the Isolated Perfused Rat Lung via Endothelin
J Pharmacol Exp Ther 2001 297: 128-132. [Abstract] [Full Text] [PDF]  

Motonori Aoki, Satoshi Yamamoto, Miki Kobayashi, Keiko Ohga, Hiroyuki Kanoh, Keiji Miyata, Kazuo Honda, and Toshimitsu Yamada

Antiasthmatic Effect of YM976, a Novel PDE4 Inhibitor, in Guinea Pigs
J Pharmacol Exp Ther 2001 297: 165-173. [Abstract] [Full Text] [PDF]  

F. W. Birke, C. J. Meade, R. Anderskewitz, G. A. Speck, and H.-M. Jennewein

In Vitro and in Vivo Pharmacological Characterization of BIIL 284, a Novel and Potent Leukotriene B₄ Receptor Antagonist
J Pharmacol Exp Ther 2001 297: 458-466. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Catherine Daniel, Jeremy Duffield, Thomas Brunner, Karin Steinmann-Niggli, Nadège Lods, and Hans-Peter Marti

Matrix Metalloproteinase Inhibitors Cause Cell Cycle Arrest and Apoptosis in Glomerular Mesangial Cells
J Pharmacol Exp Ther 2001 297: 57-68. [Abstract] [Full Text] [PDF]  

Mariona Josa, José Pérez Urizar, Javier Rapado, Carmen Dios-Viéitez, Gilberto Castañeda-Hernández, Francisco Flores-Murrieta, María Jesús Renedo, and Iñaki F. Trocóniz

Pharmacokinetic/Pharmacodynamic Modeling of Antipyretic and Anti-Inflammatory Effects of Naproxen in the Rat
J Pharmacol Exp Ther 2001 297: 198-205. [Abstract] [Full Text] [PDF]  

Armin Hatzelmann and Christian Schudt

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro
J Pharmacol Exp Ther 2001 297: 267-279. [Abstract] [Full Text] [PDF]  

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig, Lutz Wollin, Armin Hatzelmann, and Rolf Beume

In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor
J Pharmacol Exp Ther 2001 297: 280-290. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Evgeny A. Budygin, Paul E. M. Phillips, Donita L. Robinson, Andrew P. Kennedy, Raul R. Gainetdinov, and R. Mark Wightman

Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats
J Pharmacol Exp Ther 2001 297: 27-34. [Abstract] [Full Text] [PDF]  

Zheng-Hong Qin, Yumei Wang, Ren-Wu Chen, Xiaoxia Wang, Ming Ren, De-Maw Chuang, and Thomas N. Chase

Prostaglandin A₁ Protects Striatal Neurons against Excitotoxic Injury in Rat Striatum
J Pharmacol Exp Ther 2001 297: 78-87. [Abstract] [Full Text] [PDF]  

Diana L. Cichewicz, Victoria L. Haller, and Sandra P. Welch

Changes in Opioid and Cannabinoid Receptor Protein following Short-Term Combination Treatment with ⁹-Tetrahydrocannabinol and Morphine
J Pharmacol Exp Ther 2001 297: 121-127. [Abstract] [Full Text] [PDF]  

Petrus J. Pauwels, Fréderic Finana, Stéphanie Tardif, Thierry Wurch, and Francis C. Colpaert

Dynamic Dopamine-Antagonist Interactions at Recombinant Human Dopamine D_2short Receptor: Dopamine-Bound versus Antagonist-Bound Receptor States
J Pharmacol Exp Ther 2001 297: 133-140. [Abstract] [Full Text] [PDF]  

Ken Soderstrom and Frank Johnson

Zebra Finch CB1 Cannabinoid Receptor: Pharmacology and in Vivo and in Vitro Effects of Activation
J Pharmacol Exp Ther 2001 297: 189-197. [Abstract] [Full Text] [PDF]  

Galen J. Carey and Jack Bergman

Enadoline Discrimination in Squirrel Monkeys: Effects of Opioid Agonists and Antagonists
J Pharmacol Exp Ther 2001 297: 215-223. [Abstract] [Full Text] [PDF]  

Imran M. Khan, Shanaka Stanislaus, Limin Zhang, Palmer Taylor, and Tony L. Yaksh

A-85380 and Epibatidine Each Interact with Disparate Spinal Nicotinic Receptor Subtypes to Achieve Analgesia and Nociception
J Pharmacol Exp Ther 2001 297: 230-239. [Abstract] [Full Text] [PDF]  

James K. Rowlett, Walter Tornatzky, James M. Cook, Chunrong Ma, and Klaus A. Miczek

Zolpidem, Triazolam, and Diazepam Decrease Distress Vocalizations in Mouse Pups: Differential Antagonism by Flumazenil and -Carboline-3-carboxylate-t-butyl ester (-CCt)
J Pharmacol Exp Ther 2001 297: 247-253. [Abstract] [Full Text] [PDF]  

Amanda A. Harrison and Athina Markou

Serotonergic Manipulations Both Potentiate and Reduce Brain Stimulation Reward in Rats: Involvement of Serotonin-1A Receptors
J Pharmacol Exp Ther 2001 297: 316-325. [Abstract] [Full Text] [PDF]  

Matthew D. Krasowski, Andrew Jenkins, Pamela Flood, Amiinah Y. Kung, Anton J. Hopfinger, and Neil L. Harrison

General Anesthetic Potencies of a Series of Propofol Analogs Correlate with Potency for Potentiation of -Aminobutyric Acid (GABA) Current at the GABA_A Receptor but Not with Lipid Solubility
J Pharmacol Exp Ther 2001 297: 338-351. [Abstract] [Full Text] [PDF]  

Tetsuo Kiso, Yukinori Nagakura, Takashi Toya, Naoyuki Matsumoto, Seiji Tamura, Hiroyuki Ito, Masamichi Okada, and Tokio Yamaguchi

Neurometer Measurement of Current Stimulus Threshold in Rats
J Pharmacol Exp Ther 2001 297: 352-356. [Abstract] [Full Text] [PDF]  

Lance R. McMahon and Kathryn A. Cunningham

Antagonism of 5-Hydroxytryptamine_2A Receptors Attenuates the Behavioral Effects of Cocaine in Rats
J Pharmacol Exp Ther 2001 297: 357-363. [Abstract] [Full Text] [PDF]  

Megumi Shimoyama, Naohito Shimoyama, Guo-Min Zhao, Peter W. Schiller, and Hazel H. Szeto

Antinociceptive and Respiratory Effects of Intrathecal H-Tyr-D-Arg-Phe-Lys-NH₂ (DALDA) and [Dmt¹]DALDA
J Pharmacol Exp Ther 2001 297: 364-371. [Abstract] [Full Text] [PDF]  

Esther M. Chapin and Rodrigo Andrade

A 5-HT₇ Receptor-Mediated Depolarization in the Anterodorsal Thalamus. I. Pharmacological Characterization
J Pharmacol Exp Ther 2001 297: 395-402. [Abstract] [Full Text] [PDF]  

Esther M. Chapin and Rodrigo Andrade

A 5-HT₇ Receptor-Mediated Depolarization in the Anterodorsal Thalamus. II. Involvement of the Hyperpolarization-Activated Current I_h
J Pharmacol Exp Ther 2001 297: 403-409. [Abstract] [Full Text] [PDF]  

Samantha M. South, Andrew W. E. Wright, Michael Lau, Laurence E. Mather, and Maree T. Smith

Sex-Related Differences in Antinociception and Tolerance Development following Chronic Intravenous Infusion of Morphine in the Rat: Modulatory Role of Testosterone via Morphine Clearance
J Pharmacol Exp Ther 2001 297: 446-457. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lawrence H. Lash, Wei Qian, David A. Putt, Sarah E. Hueni, Adnan A. Elfarra, Renee J. Krause, and Jean C. Parker

Renal and Hepatic Toxicity of Trichloroethylene and Its Glutathione-Derived Metabolites in Rats and Mice: Sex-, Species-, and Tissue-Dependent Differences
J Pharmacol Exp Ther 2001 297: 155-164. [Abstract] [Full Text] [PDF]  

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