PERSPECTIVES IN PHARMACOLOGY:

Roberto Levi and Neil C. E. Smith

Histamine H₃-Receptors: A New Frontier in Myocardial Ischemia
J Pharmacol Exp Ther 2000 292: 825-830. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Joel W. Proksch, W. Brooks Gentry, and S. Michael Owens

Anti-Phencyclidine Monoclonal Antibodies Provide Long-Term Reductions in Brain Phencyclidine Concentrations during Chronic Phencyclidine Administration in Rats
J Pharmacol Exp Ther 2000 292: 831-837. [Abstract] [Full Text] [PDF]  

Alessandro Bertuzzi, Geltrude Mingrone, Alberto Gandolfi, Aldo Virgilio Greco, and Serenella Salinari

Disposition of Dodecanedioic Acid in Humans
J Pharmacol Exp Ther 2000 292: 846-852. [Abstract] [Full Text] [PDF]  

Johannes H. Proost, J. Mark K. H. Wierda, Martin C. Houwertjes, Jan Roggeveld, and Dirk K. F. Meijer

Structure-Pharmacokinetics Relationship of Series of Aminosteroidal Neuromuscular Blocking Agents in the Cat
J Pharmacol Exp Ther 2000 292: 861-869. [Abstract] [Full Text] [PDF]  

Vikram Arora, Derek C. Knapp, Barbara L. Smith, Mary L. Statdfield, David A. Stein, Muralimohan T. Reddy, Dwight D. Weller, and Patrick L. Iversen

c-Myc Antisense Limits Rat Liver Regeneration and Indicates Role for c-Myc in Regulating Cytochrome P-450 3A Activity
J Pharmacol Exp Ther 2000 292: 921-928. [Abstract] [Full Text] [PDF]  

Fariborz Rakhshan, Theresa A. Day, Randy D. Blakely, and Eric L. Barker

Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells
J Pharmacol Exp Ther 2000 292: 960-967. [Abstract] [Full Text] [PDF]  

Sylvie A. Terlouw, Orhangazi Tanriseven, Frans G. M. Russel, and Rosalinde Masereeuw

Metabolite Anion Carriers Mediate the Uptake of the Anionic Drug Fluorescein in Renal Cortical Mitochondria
J Pharmacol Exp Ther 2000 292: 968-973. [Abstract] [Full Text] [PDF]  

Ram K. Sindhu, Masato Mitsuhashi, and Yutaka Kikkawa

Induction of Cytochrome P-450 1A2 by Oxidized Tryptophan in Hepa lclc7 Cells
J Pharmacol Exp Ther 2000 292: 1008-1014. [Abstract] [Full Text] [PDF]  

Jill S. Warrington, Joseph W. Poku, Lisa L. von Moltke, Richard I. Shader, Jerold S. Harmatz, and David J. Greenblatt

Effects of Age on In Vitro Midazolam Biotransformation in Male CD-1 Mouse Liver Microsomes
J Pharmacol Exp Ther 2000 292: 1024-1031. [Abstract] [Full Text] [PDF]  

Gilles J. Rivière, W. Brooks Gentry, and S. Michael Owens

Disposition of Methamphetamine and Its Metabolite Amphetamine in Brain and Other Tissues in Rats after Intravenous Administration
J Pharmacol Exp Ther 2000 292: 1042-1047. [Abstract] [Full Text] [PDF]  

Hwa Jeong Lee, Britta Engelhardt, Jayne Lesley, Ulrich Bickel, and William M. Pardridge

Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse
J Pharmacol Exp Ther 2000 292: 1048-1052. [Abstract] [Full Text] [PDF]  

Els T. M. Dams, Peter Laverman, Wim J. G. Oyen, Gert Storm, Gerrit L. Scherphof, Jos W. M. van der Meer, Frans H. M. Corstens, and Otto C. Boerman

Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes
J Pharmacol Exp Ther 2000 292: 1071-1079. [Abstract] [Full Text] [PDF]  

Takahiro Yanagiya, Nobumasa Imura, Shuichi Enomoto, Yukihiro Kondo, and Seiichiro Himeno

Suppression of a High-Affinity Transport System for Manganese in Cadmium-Resistant Metallothionein-Null Cells
J Pharmacol Exp Ther 2000 292: 1080-1086. [Abstract] [Full Text] [PDF]  

Pierre-Louis Toutain, Hervé P. Lefebvre, and Jon N. King

Benazeprilat Disposition and Effect in Dogs Revisited with a Pharmacokinetic/Pharmacodynamic Modeling Approach
J Pharmacol Exp Ther 2000 292: 1087-1093. [Abstract] [Full Text] [PDF]  

Pierre-Louis Toutain, Hervé P. Lefebvre, and Valérie Laroute

New Insights on Effect of Kidney Insufficiency on Disposition of Angiotensin-Converting Enzyme Inhibitors: Case of Enalapril and Benazepril in Dogs
J Pharmacol Exp Ther 2000 292: 1094-1103. [Abstract] [Full Text] [PDF]  

Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada, and Tatsuji Iga

Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver
J Pharmacol Exp Ther 2000 292: 1118-1126. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Ravi A. Shankar, Kalman Hideg, Jay L. Zweier, and Periannan Kuppusamy

Targeted Antioxidant Properties of N-[(Tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and Its Nitroxide Metabolite in Preventing Postischemic Myocardial Injury
J Pharmacol Exp Ther 2000 292: 838-845. [Abstract] [Full Text] [PDF]  

Peter W. Stengel, Jesus Gomeza, Jurgen Wess, and Marlene L. Cohen

M₂ and M₄ Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro
J Pharmacol Exp Ther 2000 292: 877-885. [Abstract] [Full Text] [PDF]  

Xin-Liang Ma, Feng Gao, Bernard L. Lopez, Theodore A. Christopher, and Jakob Vinten-Johansen

Peroxynitrite, a Two-Edged Sword in Post-Ischemic Myocardial InjuryDichotomy of Action in Crystalloid- Versus Blood-Perfused Hearts
J Pharmacol Exp Ther 2000 292: 912-920. [Abstract] [Full Text] [PDF]  

Mervyn B. Forman, João V. Vitola, Carlos E. Velasco, John J. Murray, Raghvendra K. Dubey, and Edwin K. Jackson

Sustained Reduction in Myocardial Reperfusion Injury with an Adenosine Receptor Antagonist: Possible Role of the Neutrophil Chemoattractant Response
J Pharmacol Exp Ther 2000 292: 929-938. [Abstract] [Full Text] [PDF]  

Mahmoud M. El-Mas and Abdel A. Abdel-Rahman

Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats
J Pharmacol Exp Ther 2000 292: 944-951. [Abstract] [Full Text] [PDF]  

Carla Nau, Margaret Seaver, Sho-Ya Wang, and Ging Kuo Wang

Block of Human Heart hH1 Sodium Channels by Amitriptyline
J Pharmacol Exp Ther 2000 292: 1015-1023. [Abstract] [Full Text] [PDF]  

Hantz C. Hercule and Adebayo O. Oyekan

Cytochrome P450 /-1 Hydroxylase-Derived Eicosanoids Contribute to Endothelin_A and Endothelin_B Receptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole
J Pharmacol Exp Ther 2000 292: 1153-1160. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Graeme Griffin, Qing Tao, and Mary E. Abood

Cloning and Pharmacological Characterization of the Rat CB₂ Cannabinoid Receptor
J Pharmacol Exp Ther 2000 292: 886-894. [Abstract] [Full Text] [PDF]  

Bertold J. Vilner and Wayne D. Bowen

Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells
J Pharmacol Exp Ther 2000 292: 900-911. [Abstract] [Full Text] [PDF]  

Chung-Ren Jan, Lee-Wei Chen, and Ming-Wei Lin

Ca²⁺ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells
J Pharmacol Exp Ther 2000 292: 995-1001. [Abstract] [Full Text] [PDF]  

Ramesh Kekuda, Frederick H. Leibach, Todd C. Furesz, Carl H. Smith, and Vadivel Ganapathy

Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta
J Pharmacol Exp Ther 2000 292: 1032-1041. [Abstract] [Full Text] [PDF]  

Jin-Song Bian, Wei-Min Zhang, Jian-Ming Pei, and Tak-Ming Wong

The Role of Phosphodiesterase in Mediating the Effect of Protein Kinase C on Cyclic AMP Accumulation upon -Opioid Receptor Stimulation in the Rat Heart
J Pharmacol Exp Ther 2000 292: 1065-1070. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Songwei Wu, Min Zhang, Pamela A. Vest, Arin Bhattacharjee, Li Liu, and Ming Li

A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca²⁺ Currents in Pancreatic -Cells
J Pharmacol Exp Ther 2000 292: 939-943. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Mark J. Dresser, Andrew T. Gray, and Kathleen M. Giacomini

Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1)
J Pharmacol Exp Ther 2000 292: 1146-1152. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Alfonso Oriente, Neal S. Fedarko, Sarah E. Pacocha, Shau-Ku Huang, Lawrence M. Lichtenstein, and David M. Essayan

Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts
J Pharmacol Exp Ther 2000 292: 988-994. [Abstract] [Full Text] [PDF]  

Irmgard Tegeder, Werner Neupert, Hans Gühring, and Gerd Geisslinger

Effects of Selective and Unselective Cyclooxygenase Inhibitors on Prostanoid Release from Various Rat Organs
J Pharmacol Exp Ther 2000 292: 1161-1168. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Kristan B. Burrows, Wendy L. Nixdorf, and Bryan K. Yamamoto

Central Administration of Methamphetamine Synergizes with Metabolic Inhibition to Deplete Striatal Monoamines
J Pharmacol Exp Ther 2000 292: 853-860. [Abstract] [Full Text] [PDF]  

Marta Llansola, Pilar Monfort, and Vicente Felipo

Inhibitors of Phospholipase C Prevent Glutamate Neurotoxicity in Primary Cultures of Cerebellar Neurons
J Pharmacol Exp Ther 2000 292: 870-876. [Abstract] [Full Text] [PDF]  

Xinhui Li, George Rose, Astrid Chiari, Hui-Lin Pan, Joseph R. Tobin, and James C. Eisenach

6-NO₂-Norepinephrine Increases Norepinephrine Release and Inhibits Norepinephrine Uptake in Rat Spinal Synaptosomes
J Pharmacol Exp Ther 2000 292: 895-899. [Abstract] [Full Text] [PDF]  

Justin P. Meschler, Francis A. Clarkson, Patricia J. Mathews, Allyn C. Howlett, and Bertha K. Madras

D₂, but Not D₁ Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation in Nonhuman Primates
J Pharmacol Exp Ther 2000 292: 952-959. [Abstract] [Full Text] [PDF]  

Giorgio Sironi, Davide Colombo, Elena Poggesi, Amedeo Leonardi, Rodolfo Testa, Olivier Rampin, Jacques Bernabé, and Francois Giuliano

Effects of Intracavernous Administration of Selective Antagonists of ₁-Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs
J Pharmacol Exp Ther 2000 292: 974-981. [Abstract] [Full Text] [PDF]  

Hisashi Yamakuni, Hiroe Sawai, Yasue Maeda, Katsunori Imazumi, Hiroyuki Sakuma, Masahiko Matsuo, Seitaro Mutoh, and Jiro Seki

Probable Involvement of the 5-Hydroxytryptamine₄ Receptor in Methotrexate-Induced Delayed Emesis in Dogs
J Pharmacol Exp Ther 2000 292: 1002-1007. [Abstract] [Full Text] [PDF]  

Shelly S. Watkins, Luis Stinus, George F. Koob, and Athina Markou

Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects
J Pharmacol Exp Ther 2000 292: 1053-1064. [Abstract] [Full Text] [PDF]  

Yingying Li-Smerin, Elias Aizenman, and Jon W. Johnson

Inhibition by Intracellular Mg²⁺ of Recombinant N-Methyl-D-aspartate Receptors Expressed in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2000 292: 1104-1110. [Abstract] [Full Text] [PDF]  

Deborah A. Knobelman, Hank F. Kung, and Irwin Lucki

Regulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT_1A and 5-HT_1B Receptors
J Pharmacol Exp Ther 2000 292: 1111-1117. [Abstract] [Full Text] [PDF]  

Paulette A. Zaki, Duane E. Keith, Jr., George A. Brine, F. Ivy Carroll, and Christopher J. Evans

Ligand-Induced Changes in Surface µ-Opioid Receptor Number: Relationship to G Protein Activation?
J Pharmacol Exp Ther 2000 292: 1127-1134. [Abstract] [Full Text] [PDF]  

Rita Raddatz, Sandra L. Savic, Venkatesalu Bakthavachalam, John Lesnick, Jeffrey R. Jasper, Christopher R. McGrath, Angelo Parini, and Stephen M. Lanier

Imidazoline-Binding Domains on Monoamine Oxidase B and Subpopulations of Enzyme
J Pharmacol Exp Ther 2000 292: 1135-1145. [Abstract] [Full Text] [PDF]  

Jason M. Christie, David E. Jane, and Daniel T. Monaghan

Native N-Methyl-D-aspartate Receptors Containing NR2A and NR2B Subunits Have Pharmacologically Distinct Competitive Antagonist Binding Sites
J Pharmacol Exp Ther 2000 292: 1169-1174. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Yasuhiro Masubuchi, Shoko Yamada, and Toshiharu Horie

Possible Mechanism of Hepatocyte Injury Induced by Diphenylamine and Its Structurally Related Nonsteroidal Anti-Inflammatory Drugs
J Pharmacol Exp Ther 2000 292: 982-987. [Abstract] [Full Text] [PDF]  

ERRATA:

J Pharmacol Exp Ther 2000 292: 1175. [Full Text] [PDF]  

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