![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 296, Issue 2, 412-419, February 2001
Department of Pharmacology, Osaka University of Pharmaceutical
Sciences, Takatsuki, Osaka, Japan
We investigated the effects of pre- or post-ischemic treatment with
KB-R7943, a new Na+/Ca2+ exchange inhibitor, on
ischemic acute renal failure (ARF) in rats, and these were compared
with the effects of verapamil. Ischemic ARF was induced by clamping the
left renal pedicle for 45-min followed by reperfusion, 2 weeks after
contralateral nephrectomy. Renal function markedly decreased 24 h
after reperfusion. Pre-ischemic treatment with KB-R7943 or verapamil
attenuated the ARF-induced renal dysfunction. The
ischemia/reperfusion-induced renal dysfunction was overcome by
post-ischemic treatment with KB-R7943 but not with verapamil.
Histopathological examination of the kidney of ARF rats revealed severe
renal damage, and suppression of the damage was seen with post-ischemic
treatment with KB-R7943. KB-R7943 markedly suppressed the increment of
endothelin-1 (ET-1) content in the kidney at 2, 6, and 24 h after
reperfusion. No significant changes in Na+/Ca2+
exchanger protein expression in renal tissue were observed with 45-min
ischemia, 6 h after reperfusion and KB-R7943 treatment. These
results suggest that Ca2+ overload via the reverse mode of
Na+/Ca2+ exchange, followed by ET-1
overproduction, seems to play an important role in the pathogenesis of
the ischemia/reperfusion-induced ARF. KB-R7943, which is effective in
both cases of pre- and post-ischemic treatments, may prove to be an
effective therapeutic agent for cases of ischemic ARF.
This article has been cited by other articles:
|
|
 |
|
  N. Yang, M. Luo, R. Li, Y. Huang, R. Zhang, Q. Wu, F. Wang, Y. Li, and X. Yu Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rats Nephrol. Dial. Transplant., January 1, 2008; 23(1): 91 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Obal, K. Rascher, C. Favoccia, S. Dettwiler, and W. Schlack Post-conditioning by a short administration of desflurane reduced renal reperfusion injury after differing of ischaemia times in rats Br. J. Anaesth., December 1, 2006; 97(6): 783 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-P. Sun, M. Kohno, P. Guo, Y. Nagai, K. Miyata, Y.-Y. Fan, S. Kimura, H. Kiyomoto, K. Ohmori, D.-T. Li, et al. Involvements of Rho-Kinase and TGF-beta Pathways in Aldosterone-Induced Renal Injury J. Am. Soc. Nephrol., August 1, 2006; 17(8): 2193 - 2201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kher, K. K. Meldrum, M. Wang, B. M. Tsai, J. M. Pitcher, and D. R. Meldrum Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury Cardiovasc Res, September 1, 2005; 67(4): 594 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Luo, A. Baba, T. Matsuda, and C. Romano Susceptibilities to and Mechanisms of Excitotoxic Cell Death of Adult Mouse Inner Retinal Neurons in Dissociated Culture Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4576 - 4582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Brown, K. S. Mark, R. D. Egleton, and T. P. Davis Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1045 - C1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iwamoto, S. Kita, A. Uehara, I. Imanaga, T. Matsuda, A. Baba, and T. Katsuragi Molecular Determinants of Na+/Ca2+ Exchange (NCX1) Inhibition by SEA0400 J. Biol. Chem., February 27, 2004; 279(9): 7544 - 7553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Hung, T. Ichimura, J. L. Stevens, and J. V. Bonventre Protection of Renal Epithelial Cells against Oxidative Injury by Endoplasmic Reticulum Stress Preconditioning Is Mediated by ERK1/2 Activation J. Biol. Chem., August 1, 2003; 278(31): 29317 - 29326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yamashita, S. Kita, T. Iwamoto, M. Ogata, M. Takaoka, N. Tazawa, M. Nishikawa, K. Wakimoto, M. Shigekawa, I. Komuro, et al. Attenuation of Ischemia/Reperfusion-Induced Renal Injury in Mice Deficient in Na+/Ca2+ Exchanger J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 284 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Brown and T. P. Davis Calcium Modulation of Adherens and Tight Junction Function: A Potential Mechanism for Blood-Brain Barrier Disruption After Stroke Stroke, June 1, 2002; 33(6): 1706 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J Conway and S. V Koushik Cardiac sodium-calcium exchanger: a double-edged sword Cardiovasc Res, August 1, 2001; 51(2): 194 - 197. [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
