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Vol. 295, Issue 3, 942-950, December 2000
Department of Anatomy, Physiology, and Cell Biology, School of
Veterinary Medicine (R.C.P., C.G.P.), and California Regional Primate
Research Center (V.W.), University of California, Davis, California
Long-term exposure to the oxidant air pollutant ozone (O3)
is associated with tolerance to the acute effects of oxidant injury. To
test whether this resistance to acute injury extends to bioactivated pulmonary toxicants, male Sprague-Dawley rats were exposed to filtered
air (FA) or 0.8 ppm O3 (8 h/day) for 90 days and
administered 1-nitronaphthalene i.p. at doses of 0, 50, or 100 mg/kg.
1-Nitronaphthalene is a pulmonary cytotoxicant requiring metabolic
activation. High-resolution histopathology, transmission electron
microscopy, and morphometry revealed significantly greater
1-nitronaphthalene toxicity in the central acinar region of
O3- compared with FA-exposed rats. At 100 mg/kg, injury to
terminal bronchioles in O3-exposed rats involved denudation
of 86% of the basement membrane; 78% of the cells remaining on the
epithelium were necrotic. This is compared with denudation of 4% of
the basement membrane of FA-exposed rats administered 100 mg/kg
1-nitronaphthalene; only 25% of the cells remaining on the epithelium
were necrotic. The key difference between FA- and
O3-exposed rats treated with 1-nitronaphthalene was the
heightened severity of ciliated cell toxicity in O3-exposed animals. This is despite the fact that long-term exposure to ozone produces tolerance to oxidant stress in the epithelium of the central acinus. No differences in the susceptibility of intrapulmonary airways or trachea to 1-nitronaphthalene were observed between filtered
air- and ozone-exposed rats. This study demonstrates a site-selective
synergy between the copollutants ozone and 1-nitronaphthalene in the
production of acute lung injury.
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 K. C. Day, C. G. Plopper, and M. V. Fanucchi Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats Am J Physiol Lung Cell Mol Physiol, July 1, 2006; 291(1): L75 - L83. [Abstract] [Full Text] [PDF]
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A. M. Wheelock, B. C. Boland, M. Isbell, D. Morin, T. C. Wegesser, C. G. Plopper, and A. R. Buckpitt In Vivo Effects of Ozone Exposure on Protein Adduct Formation by 1-Nitronaphthalene in Rat Lung Am. J. Respir. Cell Mol. Biol., August 1, 2005; 33(2): 130 - 137. [Abstract] [Full Text] [PDF]
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 G. L. Baker, M. A. Shultz, M. V. Fanucchi, D. M. Morin, A. R. Buckpitt, and C. G. Plopper Assessing Gene Expression in Lung Subcompartments Utilizing In Situ RNA Preservation Toxicol. Sci., January 1, 2004; 77(1): 135 - 141. [Abstract] [Full Text] [PDF]
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 R. C. Paige, F. H. Royce, C. G. Plopper, and A. R. Buckpitt Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: I. Region-Specific Enzyme Activity J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 934 - 941. [Abstract] [Full Text]
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