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Vol. 295, Issue 2, 519-523, November 2000
Cardiac Medicine, National Heart and Lung Institute, Imperial
College School of Medicine, London, United Kingdom
In epidemiological studies tamoxifen has been associated with a
reduction in the incidence of fatal myocardial infarction in women.
However, the effects of tamoxifen on coronary artery reactivity are
unknown. We hypothesized that tamoxifen would relax precontracted
isolated rabbit coronary arteries. Rings of coronary artery from adult
male and nonpregnant female New Zealand White rabbits were suspended in
organ baths containing Krebs' solution; isometric tension was
measured. Tamoxifen (0.1-100 µM) induced significant
endothelium-dependent relaxation in precontracted rabbit coronary
arteries. This relaxation was inhibited by
N
-nitro-L-arginine methyl
ester and the estrogen receptor antagonist ICI 182,780. There
was no significant effect on calcium concentration-dependent contraction curves. These data suggest that tamoxifen has beneficial effects on coronary reactivity that could, at least in part, account for the reduction in risk of fatal myocardial infarction in women taking tamoxifen.
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