![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 292, Issue 3, 988-994, March 2000
Department of Medicine, The Johns Hopkins University School of
Medicine, Baltimore, Maryland
Interleukin (IL)-13 has been implicated in the pathogenesis of various
diseases characterized by fibrosis. We describe the effects of IL-13 on
collagen homeostasis from normal (NF) and keloid (KF) fibroblasts and
compare these effects with those of IL-4 and transforming growth factor
(TGF)-
1. Total collagen generation was up-regulated in
NF after 48 h of stimulation by IL-13; in KF, IL-13 stimulated a
more rapid collagen response. The kinetics and magnitude of collagen
generation induced by IL-13 were equivalent to those induced by similar
concentrations of IL-4 and TGF-1. Collagen type I
production paralleled total collagen generation from both NF and KF;
however, IL-4-induced collagen type I and total collagen production
from KF was more transient than that induced by either IL-13 or
TGF-1. Procollagen 1
1 gene expression was induced in
KF by stimulation with IL-13 for 24 h. Moreover, IL-13 was unique
among these three cytokines in its ability to induce gene expression
for procollagen 31. Finally, IL-13 inhibited IL-1-induced matrix
metalloproteinase (MMP)-1 and MMP-3 production and enhanced tissue
inhibitor of metalloproteinase (TIMP)-1 generation from NF; although
similar effects were observed with IL-4, TGF-1 transiently enhanced MMP-1 and MMP-3 generation without effecting TIMP-1. In KF, IL-13 and IL-4 inhibited MMP-3, whereas
TGF-1 enhanced MMP-3; TIMP-1 was unaffected by any of
the three cytokines. These data demonstrate both the profibrotic
effects of IL-13 on collagen homeostasis and the potential differential
regulation of collagen homeostasis in fibroblast subtypes by IL-13.
This article has been cited by other articles:
|
|
 |
|
  H. K. Jessup, A. W. Brewer, M. Omori, E. A. Rickel, A. L. Budelsky, B.-R. P. Yoon, S. F. Ziegler, and M. R. Comeau Intradermal Administration of Thymic Stromal Lymphopoietin Induces a T Cell- and Eosinophil-Dependent Systemic Th2 Inflammatory Response J. Immunol., September 15, 2008; 181(6): 4311 - 4319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Amatucci, T. Novobrantseva, K. Gilbride, M. Brickelmaier, P. Hochman, and A. Ibraghimov Recombinant ST2 boosts hepatic Th2 response in vivo J. Leukoc. Biol., July 1, 2007; 82(1): 124 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. N. Lama, H. Harada, L. N. Badri, A. Flint, C. M. Hogaboam, A. McKenzie, F. J. Martinez, G. B. Toews, B. B. Moore, and D. J. Pinsky Obligatory Role for Interleukin-13 in Obstructive Lesion Development in Airway Allografts Am. J. Pathol., July 1, 2006; 169(1): 47 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Barbarin, Z. Xing, M. Delos, D. Lison, and F. Huaux Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L841 - L848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Moore, J. E. Kolodsick, V. J. Thannickal, K. Cooke, T. A. Moore, C. Hogaboam, C. A. Wilke, and G. B. Toews CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury Am. J. Pathol., March 1, 2005; 166(3): 675 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cavarra, F. Carraro, S. Fineschi, A. Naldini, B. Bartalesi, A. Pucci, and G. Lungarella Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1186 - L1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Belperio, M. Dy, L. Murray, M. D. Burdick, Y. Y. Xue, R. M. Strieter, and M. P. Keane The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis J. Immunol., October 1, 2004; 173(7): 4692 - 4698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jinnin, H. Ihn, K. Yamane, and K. Tamaki Interleukin-13 Stimulates the Transcription of the Human {alpha}2(I) Collagen Gene in Human Dermal Fibroblasts J. Biol. Chem., October 1, 2004; 279(40): 41783 - 41791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaviratne, M. Hesse, M. Leusink, A. W. Cheever, S. J. Davies, J. H. McKerrow, L. M. Wakefield, J. J. Letterio, and T. A. Wynn IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-{beta} Independent J. Immunol., September 15, 2004; 173(6): 4020 - 4029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jakubzick, E. S. Choi, K. J. Carpenter, S. L. Kunkel, H. Evanoff, F. J. Martinez, K. R. Flaherty, G. B. Toews, T. V. Colby, W. D. Travis, et al. Human Pulmonary Fibroblasts Exhibit Altered Interleukin-4 and Interleukin-13 Receptor Subunit Expression in Idiopathic Interstitial Pneumonia Am. J. Pathol., June 1, 2004; 164(6): 1989 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Jakubzick, E S Choi, S L Kunkel, H Evanoff, F J Martinez, R K Puri, K R Flaherty, G B Toews, T V Colby, E A Kazerooni, et al. Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia J. Clin. Pathol., May 1, 2004; 57(5): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Kolodsick, G. B. Toews, C. Jakubzick, C. Hogaboam, T. A. Moore, A. McKenzie, C. A. Wilke, C. J. Chrisman, and B. B. Moore Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts J. Immunol., April 1, 2004; 172(7): 4068 - 4076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kaufman, P. J. Sime, and R. P. Phipps Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN-{gamma} and IL-13, and Implications for Fibrosis J. Immunol., February 1, 2004; 172(3): 1862 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. Sandler, M. M. Mentink-Kane, A. W. Cheever, and T. A. Wynn Global Gene Expression Profiles During Acute Pathogen-Induced Pulmonary Inflammation Reveal Divergent Roles for Th1 and Th2 Responses in Tissue Repair J. Immunol., October 1, 2003; 171(7): 3655 - 3667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al. Idiopathic Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105. [Full Text] [PDF]
|
|
|
|
|
|
M. P. Chung, M. M. Monick, N. Y. Hamzeh, N. S. Butler, L. S. Powers, and G. W. Hunninghake Role of Repeated Lung Injury and Genetic Background in Bleomycin-Induced Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 375 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jakubzick, E. S. Choi, B. H. Joshi, M. P. Keane, S. L. Kunkel, R. K. Puri, and C. M. Hogaboam Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells J. Immunol., September 1, 2003; 171(5): 2684 - 2693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jakubzick, E. S. Choi, S. L. Kunkel, B. H. Joshi, R. K. Puri, and C. M. Hogaboam Impact of Interleukin-13 Responsiveness on the Synthetic and Proliferative Properties of Th1- and Th2-Type Pulmonary Granuloma Fibroblasts Am. J. Pathol., May 1, 2003; 162(5): 1475 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Huaux, T. Liu, B. McGarry, M. Ullenbruch, and S. H. Phan Dual Roles of IL-4 in Lung Injury and Fibrosis J. Immunol., February 15, 2003; 170(4): 2083 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Leonardi, R. Cortivo, I. Fregona, M. Plebani, A. G. Secchi, and G. Abatangelo Effects of Th2 Cytokines on Expression of Collagen, MMP-1, and TIMP-1 in Conjunctival Fibroblasts Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 183 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Belperio, M. Dy, M. D. Burdick, Y. Y. Xue, K. Li, J. A. Elias, and M. P. Keane Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 419 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jakubzick, S. L. Kunkel, B. H. Joshi, R. K. Puri, and C. M. Hogaboam Interleukin-13 Fusion Cytotoxin Arrests Schistosoma mansoni Egg-Induced Pulmonary Granuloma Formation in Mice Am. J. Pathol., October 1, 2002; 161(4): 1283 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Skinnider and T. W. Mak The role of cytokines in classical Hodgkin lymphoma Blood, May 29, 2002; 99(12): 4283 - 4297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, C. Jakubzick, J. M. Schuh, B. H. Joshi, R. K. Puri, and C. M. Hogaboam IL-13 Fusion Cytotoxin Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice J. Immunol., December 1, 2001; 167(11): 6583 - 6592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Lee, R. J. Homer, Z. Zhu, S. Lanone, X. Wang, V. Koteliansky, J. M. Shipley, P. Gotwals, P. Noble, Q. Chen, et al. Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor {beta}1 J. Exp. Med., September 17, 2001; 194(6): 809 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Strieter Mechanisms of Pulmonary Fibrosis : Conference Summary Chest, July 1, 2001; 120(2007): 77S - 85S. [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, T. Kohyama, H. Wang, Y. K. Zhu, F.-Q. Wen, H. J. Kim, D. J. Romberger, and S. I. Rennard Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L1049 - L1056. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
